H3B-5942 free base

Name	H3B-5942
Synonyms	H3B-5942 H3B-5942 free base 2-Butenamide, 4-[[2-[4-[(1E)-1-(1H-indazol-5-yl)-2-phenyl-1-buten-1-yl]phenoxy]ethyl]amino]-N,N-dimethyl-, (2E)-
CAS	2052128-15-9

Molecular Formula	C31H34N4O2
Molar Mass	494.63
Density	1.157±0.06 g/cm3(Predicted)
Boling Point	717.7±60.0 °C(Predicted)
Solubility	DMSO : 83.33 mg/mL (168.47 mM; Need ultrasonic)
pKa	14.20±0.40(Predicted)
Storage Condition	-20°C
In vitro study	H3B-5942 targeting Cys530, both wild-type and mutant ERα were inactivated. Once bound to ERα, the H3B-5942 allows the DNA-binding domain of ERα to bind to the promoter and enhancer regions containing the ERE, inducing ERα to transition to a transcriptionally repressed conformation via the coactivator. In a series of containing ER alpha.
In vivo study	In the expression of Er alpha.

Last Update：2024-01-02 23:10:35

biological activity	H3B-5942 is a selective, irreversible, ERα WT and ERα mutants were inactivated with Ki values of 1 nM and 0.41 nM, respectively.
Target	Value
ERα (Y537S) ()	0.41 nM(Ki)
ERα WT ()	1 nM(Ki)

Last Update：2024-04-10 22:29:15

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CAS: 2052128-15-9
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Product Name: H3B-5942 Visit Supplier Webpage Request for quotation
CAS: 2052128-15-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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H3B-5942 free base

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